I use Opera as a mail client, so Thuderbird is useless for me. I set Opera Mail as a default client in my settings. But the indicator plugin has all the actions tied to Thunderbird. I prefer indicator, because it allows adjusting the volume by hover & scroll. Email icon should be removable, or it should lead to the default email client.
Os: Xubuntu 11.10
The plugin shows pretty much every app that registered itself for that, the plugin just consumes what indicator-messages throws at it.